antibodiesReviewEffectofIntrinsicandExtrinsicFactorsonthePharmacokineticsofAntibody–DrugConjugates(ADCs)IftekharMahmoodMahmoodClinicalPharmacologyConsultancy,LLC.,Rockville,MD20850,USA;Iftekharmahmood@aol.com;Tel.:+1-301-838-4555Abstract:Antibody–drugconjugates(ADCs)arecomplexmoleculeswhereinamonoclonalantibodyislinkedtoabiologicallyactivedrug(asmallmolecule),formingaconjugate.Initially,mostoftheADCsweredevelopedandarebeingdevelopedforthetreatmentofcancer;however,withtime,ithasbeenrealizedthatADCscanalsobedevelopedtomanageorcureotherdiseases.Pharmacokinetics(PK)playsanimportantroleinmodern-daydrugdevelopmentandtheknowledgeofPKiscrucialindesigningasafean...